Good afternoon
I built the physiologically based pharmacokinetic (PBPK) model of nanoparticles. It has 10 compartments, about 30 parameters.
When I try to fit my model to experimental data (Fit Data), Matlab either freezes (does not respond to requests, I have to restart it), or it takes a very long time after which it gives an error (for example, the matrix is singular). If the data fitting begins, no more than 10 iterations take place, after which the fitting ends and the obtained values have a huge error. So I could not approximate the data, even for one compartment and two or three parameters.
At the same time, changing the model parameters during the simulation leads to change in the shape of the curve, but I can’t fit all the parameters.
Verification of the model does not find any error in the model. All other functions work normally (simulation, sensitivity analysis).
My data was imported from a .txt file.
What could be the problem?
You can get the file from the link: https://yadi.sk/d/H_-I0nn6gcdIfg.
The data: https://yadi.sk/d/_NgTLpOac_stzA
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