MATLAB: Transit Compartments with Simbiology

Question

Do you have a good example in Simbiology for me modify the built-in PK models that would create 3 transit compartments prior to absorption.

Basically, I would like to create a one-compartmental PK model with 3 transit compartments and then the standard Ka parameter with first order dosing. I then want to do the same for a 2-compartmental PK model with 3 transit compartments prior to absorption.

Example 1: V, CL, Ka, MTT and Example 2: Vc, CL, Q, Vp, MTT

I attempted to use the gPKPDSim package and thought to use the standard Simbiology interface instead.

Andy

Answer 1

Have you seen the documentation example Estimate Pharmacokinetic Parameters Using SimBiology Desktop? It walks you through selecting a PK model from the built-in library within SimBiology. You should see that there are several options for 3-compartment models. See if any of those are a good starting point for you.