YourTable.Properties.VariableNames = regexprep(YourTable.Properties.VariableNames, '_', 'XXX');
Change the 'XXX' to the thing you want the '_' replaced with. The replacement characters must be chosen from '' (empty) or 'A':'Z' or 'a':'z' or '0':'9' or '_' -- in other words the VariableNames are restricted to being valid MATLAB variable names.
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