MATLAB: How can Simbiology dosing be administered continuously instead of discretely

Question

How can dosing be administered continuously instead of discretely?

Here is what I am currently trying:

-Start the Simbiology App

-Add a Linear {Clearance, Volume} Infusion Model

-Add a "schedule dose" to the model under "Dose_Central"

-Double click green table next to 'dose_1'

-Click "Editor…" button

I am unsure of how to specify the dosage so that it is continuous instead of providing a discrete amount at each time. I have looked through some documentation on dosing but was unclear if there was an easy way to change the 'rate' to accomplish this.

https://www.mathworks.com/help/simbio/ref/rate.html

 

Answer 1

There are two ways to implement continuous dosing: 

1) Use a repeat or scheduled dose with just one dose starting at t=0. You can set the 'rate' parameter to the rate you need and set the 'amount' parameter to a large number. This way, the total amount will never be reached and the dose is given continuously. Your 'amount' should be larger than 'rate*(duration of simulation)'

 

2) Instead of a dose object you can introduce a reaction “null -> species” reaction with a rate parameter k and mass action kinetics. This describes a continuous synthesis or dosing of “species”.