The answers to this question contain pdf cropping utilities that will give smaller files than Eric Doviak's original, but as far as I can tell they only work in Linux.
Is there a way to make them work in Windows, or an equivalent native utility? I also need to be able to run it from command line.
(Motivation: I managed to get fancy-preview running for my dissertation, but it turns my 50-page dissertation from a compact 1MB into 10MB. I understand this as due to a large number of uncompressed tooltips being embedded, and would like to avoid that.)
Best Answer
Check out PDF manipulation tips, Part 1. I haven't used this functionality before myself, but ghostscript can apparently handle this from the command line with:
where -dPDFSETTINGS is used to define how images are resampled. Using
-dPDFSETTINGS=/screen
will yield dpi=72. I just tried this with a sample pdf and it seems to work fine.