In radiotherapy, the goal is to kill as many cancer cells in a localised area without killing normal cells right? So what possible reason would there be to use gamma irradiation over alpha irradiation?
Gamma is not as good at ionising and damaging cells and atoms that make them up as alpha is. it is also very good transmitting through hard AND soft surfaces so gamma irradiation results in much more collateral damage than alpha irradiation. Alpha particles are absorbed easily and cause more damage to cells.
So why are gamma waves used instead of alpha particles in radiotherapy?
Best Answer
Gamma radiation is used when the radiation source is outside the body and we need to focus it into a tumor that's inside it. For these situations, if we used alpha radiation, it would just get stopped at the skin, which is definitely not a good thing.
This type of external-beam therapy can also be done with charged particles, known as particle therapy, in which case you have the advantage that the sources can be more consistent and that you have better control over the focusing (since you can use electrostatic lenses and magnetic fields to shape the beam). However, once you're in that arena, proton therapy is likely to have every advantage of helium-ion beams, and it will be much easier to produce.
Alpha emitters are good in situations where you can get them right next to the tumor cells you want to kill, which probably means that you're including the alpha emitter in some biochemically-active molecule (a radiopharmaceutical) that gets preferentially concentrated in the tumor.
This does seem to be used in practice, though it seems that most therapies of this type use beta emitters, which have a slightly larger radius of action.