If the functional derivative
$$\tag{1} \frac{\delta F[\phi]}{\delta\phi^{\alpha}(x)} $$
exists (wrt. to a certain choice of boundary conditions), it obeys infinitesimally
$$\tag{2}\delta F ~:=~ F[\phi+\delta\phi]- F[\phi] ~=~\int_M \!dx\sum_{\alpha\in J} \frac{\delta F[\phi]}{\delta\phi^{\alpha}(x)}\delta\phi^{\alpha}(x). $$
OP's functional integral formula
$$\tag{3} \int [d\phi ]\frac{\delta F[\phi]}{\delta\phi^{\alpha}(x)} ~=~ 0$$
is really a shorthand for infinitely many integrations
$$\tag{4} \left[\prod_{y\in M,\beta\in J} \int d\phi^{\beta}(y) \right]\frac{\delta F[\phi]}{\delta\phi^{\alpha}(x)} ~=~ 0.$$
Before we can proceed, the functional integral measure in (4) must be given a mathematical definition. The precise definition depends on context and method. Needless to say that a general mathematically rigorous definition of functional integrals is a well-known open problem in mathematics. For instance, one may try to construct the functional integral as an appropriate continuum limit of a discretized space-time $M$, as Michael Brown suggests in a comment.
Let us use DeWitt's condensed notation, where all indices (both continuous and discrete indices) are lumped together as
$$\tag{5} i~=~(\alpha,x)~\in~ I~:=~ J\times M,$$
and fields are written as
$$\tag{6} \phi^i ~:=~ \phi^{\alpha}(x)~,\qquad i~\in~ I.$$
We now discretize space-time $M$. The discretization means that we think of $I$ as a finite index-set. In other words, we now only have finitely many variables $\phi^i$, $i\in I$, in the theory. The functional derivative (1) [times$^1$ the volume $\Delta x$ of a single cell of the discretization] is replaced by a partial derivative
$$\tag{1'} \frac{\partial F[\phi]}{\partial\phi^{i}}. $$
An infinitesimally variation is given by the standard formula from calculus in several variables
$$\tag{2'}\delta F ~:=~ F[\phi+\delta\phi]- F[\phi] ~=~\sum_{i\in I} \frac{\partial F[\phi]}{\partial\phi^{i}}\delta\phi^{i}. $$
Finally, OP's functional integral formula (4) becomes
$$\tag{4'} \left[\prod_{j\in I} \int d\phi^{j} \right] \frac{\partial F[\phi]}{\partial\phi^{i}}~=~ 0.$$
Equation (4') follows from the fact that an integral of a total derivative vanishes if the boundary contributions are zero.
--
$^1$ Concerning dimensions of functional derivatives versus partial derivatives, see also this Phys.SE post.
Contrary to your claim near the end of your question, I claim that the time-derivative of the field is being treated as an "independent" argument of the Lagrangian. I'll try to convince you of this by showing you how this independence leads to everything working out the way you think it should. Some of the key points are at the end, so please read all the way through before you succumb to skepticism.
For the sake of simplicity, let's assume from the start that we are considering a classical theory of fields $\phi:\mathbb R^2\to\mathbb R$. Let $\mathcal F$ denote the set of admissible fields in this theory. We denote the first field argument with $t$ and the second argument with $x$, so we write $\phi(t,x)$ as usual.
Ok so, now let's turn to the Lagrangian. To describe this correctly, imagine taking the $x$ argument of a field in our theory fixed, then this yields a real-valued function of a single, real variable $\phi(\cdot, x):\mathbb R\to\mathbb R$. Suppose that $\mathcal G$ denotes the set of such functions. Then the Lagrangian can be defined as a functional $L:\mathcal F\times\mathcal F\to\mathcal G$. In other words, it takes in two functions that map $\mathbb R^2\to\mathbb R$ and outputs a function that maps $\mathbb R\to\mathbb R$. We label the first argument suggestively by $\phi$ and the second argument suggestively by $\dot \phi$, but in principle, one can evaluate $L$ on whatever fields $\phi$ and $\psi$ that one chooses and write, for example $L[\phi, \psi]$.
I claim that the definitions of the relevant functional derivatives are as follows:
\begin{align}
\frac{\delta L}{\delta \phi(t,x)}[\phi,\dot\phi](t)
&= \lim_{\epsilon\to 0}\frac{L[\phi+\epsilon\Delta_x,\dot\phi](t)-L[\phi,\dot\phi](t)}{\epsilon} \\
\frac{\delta L}{\delta \dot\phi(t,x)}[\phi,\dot\phi](t)
&= \lim_{\epsilon\to 0}\frac{L[\phi,\dot\phi+\epsilon\Delta_x](t)-L[\phi,\dot\phi](t)}{\epsilon}
\end{align}
where, I am using the notation
\begin{align}
\Delta_{x}(t,x') = \delta(x'-x)
\end{align}
Notice that this is essentially like taking partial derivatives because we vary the arguments of $L$ independently.
Now, suppose that we have a theory described by a Lagrangian density that is a local function of the field and its first derivatives. Then the Lagrangian density is defined as a function $\mathscr L:\mathbb R^3\to\mathbb R$, and, because we anticipate that we will be putting the values of the field and its derivatives into the arguments of the Lagrangian density, we label its three arguments with the symbols $\phi, \dot \phi, \phi'$. The symbols $\dot\phi$ and $\phi'$ are supposed to suggestively indicate that the arguments of the Lagrangian density are meant to be evaluated on the values of a field and its time and space derivative. This is, of course, a bit of an abuse of notation since $\phi$ is usually reserved as a symbol for the field, a function $\mathbb R^2\to\mathbb R$, not for the values of the field. But as long as we keep this abuse of notation in mind, we shouldn't get confused. Then we have
\begin{align}
L[\phi, \dot\phi](t) = \int dx' \,\mathscr L(\phi(t,x'), \dot\phi(t,x'), \phi'(t,x'))
\end{align}
Now let's apply the definitions of the functional derivatives above and see what we get. For one thing, we have
\begin{align}
\frac{\delta L}{\delta \dot\phi(t,x)}[\phi,\dot\phi](t)
&= \lim_{\epsilon\to0}\frac{\int dx'\,\mathscr{L}(\phi(t,x'),\dot{\phi}(t,x')+\epsilon\delta(x'-x),\partial_{x'}\phi(t,x'))-\int dx'\,\mathscr{L}}{\epsilon} \\
&= \int dx'\,\frac{\partial\mathscr L}{\partial \dot\phi}(\phi(t,x'), \dot\phi(t,x'), \phi'(t,x'))\,\delta(x'-x) \\
&= \frac{\partial\mathscr L}{\partial \dot\phi}(\phi(t,x),\dot\phi(t,x),\phi'(t,x))
\end{align}
which is exactly what you said you should get in your question. Similarly, I'll leave it to you to show that the definition above yields
\begin{align}
\frac{\delta L}{\delta \phi(t,x)}[\phi,\dot\phi](t)
&= \frac{\partial\mathscr L}{\partial \phi}(\phi(t,x),\dot\phi(t,x),\phi'(t,x)) \\ &\hspace{2cm}-\frac{\partial}{\partial x}\left[\frac{\partial\mathscr L}{\partial \phi'}(\phi(t,x),\dot\phi(t,x),\phi'(t,x))\right]
\end{align}
or, if we relax the notation a bit since we know what we're doing now, we can summarize this as
\begin{align}
\frac{\delta L}{\delta \dot\phi} = \frac{\partial\mathscr L}{\partial\dot\phi}, \qquad \frac{\delta L}{\delta \phi} = \frac{\partial \mathscr L}{\partial \phi} - \frac{\partial}{\partial x}\frac{\partial \mathscr L}{\partial \phi'}
\end{align}
Now, suppose that we want to obtain the Euler-Lagrange equations. For this, we define the action for our theory as a function $S:\mathcal F\to\mathbb R$ as follows:
\begin{align}
S[\phi]=\int dt \,L[\phi, \dot\phi](t)
\end{align}
Notice that here, the symbol $\dot\phi$ does denote the partial time-derivative of the field $\phi$, namely $\dot\phi = \partial_t\phi$. The key point here is that even though the arguments of the Lagrangian are independent, we always have the freedom to evaluate the arguments on a field and its derivative which are certainly not independent. In particular, this means that if we vary the action, then in the integral on the right hand side, we can perform the sort of integration by parts that you were worried we wouldn't be able to do. In fact, if you vary the action, then you'll find that
\begin{align}
\delta S[\phi]
&= \int dt\,dx\,\left[\frac{\delta L}{\delta\phi} - \frac{\partial}{\partial t}\frac{\delta L}{\delta\dot\phi}\right]\delta\phi
\end{align}
so setting the variation to zero, and using the results I derived above using the claimed definitions of the partial variational derivatives, we obtain the standard Euler-Lagrange equations
\begin{align}
\frac{\partial \mathscr L}{\partial \phi} -\frac{\partial}{\partial t}\frac{\partial \mathscr L}{\partial \dot\phi} - \frac{\partial}{\partial x}\frac{\partial \mathscr L}{\partial \phi'}=0.
\end{align}
Best Answer
Hints to the question (v2):
First of all, one should realize the abuse of notation in eq. (6.69) of Ref. 1 where $\phi$ is used in two meanings: both as an external parameter and as internal integration/dummy variable. It is more properly written as $$ \widehat {Z}[\phi]~=~\frac{{e}^{iS[\phi]}}{{\cal N}}, \qquad {\cal N}~:=~\int\!{\cal D}\phi~e^{iS[\phi]} .\tag{6.69'}$$
Similarly, eq. (6.72) is essentially equivalent to $$ \frac { \delta \widehat { Z } [\phi ] }{ \delta \phi(x)} ~=~\frac{1}{\cal N} \frac {\delta {e}^{iS[\phi]} }{ \delta \phi(x)} ~=~\frac{{e}^{iS[\phi]}}{{\cal N}}\frac{\delta S[\phi ]}{\delta\phi(x) } ~=~\widehat { Z } [\phi ]\frac{\delta S[\phi ]}{\delta\phi(x) }.\tag{6.72'} $$ In the first equality we stress that we shouldn't differentiate the denominator ${\cal N}$ wrt. $\phi(x)$ because the denominator ${\cal N}$ doesn't depend on $\phi(x)$, cf. comment by David Vercauteren.
Finally, the functional derivative $\frac{\delta S[\phi ]}{\delta\phi(x) }$ becomes the Euler-Lagrange expression.
References: