The error indicates that your user account does not have permission to write to the pathdef.m file, or the folder that it is located in.
You will need to insure your account has permission to write to the pathdef.m file, or you will need to use an account that has permission to write to the pathdef.m file to install the software. Contact your local system administrator for assistance with permissions.
The pathdef.m file can be located by running "which pathdef.m" in the MATLAB command window. By default, it will be in:
$MATLAB_ROOT\toolbox\local\pathdef.m
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