MATLAB: Remove noise of the signal with some commands

denoisingdiastolicecgheartmedicalnoiseremove noisesystolic

I have data of aorta signals of patients in which I have to remove the noise which is present in the middle of the signals. I want a clean signal in which I should identify systolic peaks, diastolic peaks and so on (for this I have a function to identify). Can anyone help me out to remove or delete permanently the noise from the existing signal? I want to remove the gaps in the signal and there are some huge peaks lines that I want to remove as well.
Thank you for your help and your time.
I appreciate the help.
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