MATLAB: In Simbiology, should the categorical variables be assigned as group variable or covariate in the dataset

SimBiology

I am using Simbiology for population pharmacokinetic model development. I use non-linear mixed effect modelling approach. I have a doubt in the intial assignment of data type in the dataset.

Suppose I have age and gender in the dataset. Clearly, I will assign age as covariate. Now gender is also a covariate. But there is a option in the dataset type which is group variable.

Now I am confused on whether I should assign gender as covariate or group variable.?

I am attaching a screenshot for the reference.

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Oh. That's a clear answer. I have a logical query. Among the covariate, one is a categorical variable (gender) and another is a continuous variable (age). How do I incorporate this information in the dataset / modelling?

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MATLAB: How to simulate simbiology model using array of doses

In your code, dose_sc and dose_iv contain both all doses in your model.

You should specify the name of a SC or IV dose that is already contained in your model. The purpose of passing dose_sc and dose_iv to createDoses is mainly to specifiy the target name. So an alternative could be to create dose templates:

dose_iv  = sbiodose('IV','TargetName','your_iv_target_species');
dose_SC  = sbiodose('SC','TargetName','your_sc_target_species');

MATLAB: Do simfunctions support parameterized dosing

Yes, parameterized doses are supported with SimFunctions. However, you cannot change the type of parameterization after creating a SimFunction. In your example, you created a SimFunction with a dose that was not parameterized, so you cannot simulate it with a parameterized dose table.

To create a SimFunction that uses a parameterized dose, replace your input {'drug'} with a "template" dose object that is parameterized. For example, you can re-use your existing dose for this by changing the next-to-last line of code to the following:

simFunction = createSimFunction(model,{},{'drug'},dose);

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Related Solutions

MATLAB: How to simulate simbiology model using array of doses

MATLAB: Do simfunctions support parameterized dosing

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