MATLAB: Has anyone a minimize vehicles or routes part of algorithm

minimize routesminimize vehiclesvrp

I have a problem that wants to minimize the routes (Vrp problem) and i want a code for it

lsqcurvefit is better for a problem of that form.
Are you supplying your own derivative calculations using the GradObj option (and Hessian option if applicable)? You should do so, since the analytical derivatives are easy here. With lsqcurvefit, there are similar options, e.g. Jacobian.
How are you initializing the optimization? Because your model is loglinear, it is likely that the initial guess as generated below will be more effective than random guessing.

      n=numel(Y);
      x0=[ones(n,1) X1(:), X2(:)]\log(Y(:)); %x0=[a;b_1;b_2]

You are not passing the fixed parameter variables MEdp, t, MEp, F, L, S to the objective. One way to do so is,

fun=@(E) objective(E, MEdp, t, MEp, F, L, S);
Eoptimized = fmincon(fun, E, [],[])