You need a lowpass filter. You can use fdesign.lowpass. There are many possible specification strings. You have not stated all your specs, like how many dB of attenuation you wish to have. I'll create an example with 50 dB and obtain both an FIR filter (Hd1) and an IIR filter(Hd2)
d = fdesign.lowpass('Fp,Fst,Ap,Ast',1000,1200,0.5,50,1e4);
Hd1 = design(d,'equiripple');
Hd2 = design(d,'butter');
t = 0:1e-4:1;
x = cos(2*pi*500*t)+0.5*cos(2*pi*2000*t)+randn(size(t));
out = filter(Hd1,x);
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