No requirement for $f$ to have real coefficients was stated. So you could have
e.g. $f(x) = (x-1)(x-4)(x+i)$ which has two real roots, and $f(x^2)$ has the four distinct real roots $\pm 1$ and $\pm 2$.
Yes, there is. You know that your roots (including multiplicities) can be expressed as $\{a, a, -a+δ, -a-δ\}$ (because the sum is zero after the normalization). Expand
$$(x-a)^2(x+a-δ)(x+a+δ) = x^4 - (2a^2 + δ^2)x^2 + 2aδ^2 x + a^4-δ^2a^2$$
and compare with your form. Next, note that the equations
$$\begin{aligned}
- (2a^2 + δ^2) &= q \\
a^4-δ^2a^2 &= s
\end{aligned}$$
can be both expressed using
$$A = a^2, D = δ^2$$
and they only lead to a quadratic equation for $A$. It's easy from there. You'll get $a^2$ but the sign of $a$ is correlated with the sign of the linear term (which otherwise only contains factors of a 2 and a square).
Generally:
$$\bbox[7px,border:2px solid]{a = (\mathop{\rm sgn} r)\cdot \sqrt{\frac{-q \pm \sqrt{q^2 + 12s}}6}}\ .$$
The sign inside the square root needs to be chosen so that $2aD = -2a(q+2a^2) = r$. For $s > 0$ only + guarantees a real $a$ but if $s < 0$ then both signs lead to a real solution and one of them corresponds to a quartic with a different $r$.
Example:
$$\begin{aligned}
p(x) &= x^4 - 19x^2 + 6x + 72 \\
⇒ 2A + D &= 19 \\
A^2 - AD &= 72 \\
⇒ A^2 - A(19-2A) = 3A^2 - 19A &= 72 \\
⇒ A &= \frac{19 \pm \sqrt{1225}}{6} = \frac{19 \pm 35}6, \quad D = 19-2A \\
A ≥ 0 ⇒ A &= 9, \quad D = 1 \\
⇒ a &= 3, d = 1
⇒ p(x) = (x-3)^2 (x+2) (x+4)
\end{aligned}$$
Best Answer
A simpler approach: For a symmetric polynomial, if $x$ is a root, then so is $\frac{1}{x}$. So for there to be only three real roots, one of the roots must be $\pm 1$.
But that means either $13-2k=0$ or $13+2k=0$. Then you have to check that there are two other real roots in those cases.
This is related to the solution others have given by creating a polynomial of $x+\frac{1}{x}$ - any symmetric polynomial (that is, with coefficients reading the same forwards and back) can be written as a polynomial of $x+\frac1x$ times a power of $x$.