Looking at the $2 \times 2$ and $3 \times 3$ forms of this matrix, we see that:
$\det \begin{bmatrix} t & -a_0 \\ -1 & t-a_1 \end{bmatrix} = t(t-a_1) - a_0 = t^2 - a_1t - a_0$
and, by expansion along the first row:
$\det \begin{bmatrix} t & 0 & -a_0 \\ -1 & t & -a_1 \\ 0 & -1 & t-a_2 \end{bmatrix} = t \times\det \begin{bmatrix} t & -a_1 \\ -1 & t-a_2 \end{bmatrix} + (-a_0) \det\begin{bmatrix} -1 & t \\ 0 & -1 \end{bmatrix}$
$= t[t(t-a_2) - a_1] - a_0 = t^3 - a_2t^2 - a_1t - a_0 $
So it looks like:
$\det \begin{bmatrix} t & 0 & 0 & \cdots & 0 & -a_0 \\ -1 & t & 0 & \cdots & 0 & -a_1 \\ 0 & -1 & t & \cdots & 0 & -a_2 \\ 0 & 0 & -1 & \cdots & 0 & -a_3 \\ \vdots & \vdots & \vdots & \ddots & \vdots & \vdots \\ 0 & 0 & 0 & \cdots & t & -a_{n-1} \\ 0 & 0 & 0 & \cdots & -1 & t-a_n \end{bmatrix} = t^{n+1} - a_nt^n - a_{n-1}t^{n-1} - ... - a_2t^2 - a_1t - a_0$
Which we can prove by induction.
Assume that:
$\det \begin{bmatrix} t & 0 & 0 & \cdots & 0 & -a_0 \\ -1 & t & 0 & \cdots & 0 & -a_1 \\ 0 & -1 & t & \cdots & 0 & -a_2 \\ 0 & 0 & -1 & \cdots & 0 & -a_3 \\ \vdots & \vdots & \vdots & \ddots & \vdots & \vdots \\ 0 & 0 & 0 & \cdots & t & -a_{n-2} \\ 0 & 0 & 0 & \cdots & -1 & t-a_{n-1} \end{bmatrix} = t^{n} - a_{n-1}t^{n-1} - a_{n-2}t^{n-2} - ... - a_2t^2 - a_1t - a_0$
Then, by expansion along the first row:
$\det \begin{bmatrix} t & 0 & 0 & \cdots & 0 & -a_0 \\ -1 & t & 0 & \cdots & 0 & -a_1 \\ 0 & -1 & t & \cdots & 0 & -a_2 \\ 0 & 0 & -1 & \cdots & 0 & -a_3 \\ \vdots & \vdots & \vdots & \ddots & \vdots & \vdots \\ 0 & 0 & 0 & \cdots & t & -a_{n-1} \\ 0 & 0 & 0 & \cdots & -1 & t-a_n \end{bmatrix} = t \det \begin{bmatrix} t & 0 & 0 & \cdots & 0 & -a_1 \\ -1 & t & 0 & \cdots & 0 & -a_2 \\ 0 & -1 & t & \cdots & 0 & -a_3 \\ 0 & 0 & -1 & \cdots & 0 & -a_4 \\ \vdots & \vdots & \vdots & \ddots & \vdots & \vdots \\ 0 & 0 & 0 & \cdots & t & -a_{n-1} \\ 0 & 0 & 0 & \cdots & -1 & t-a_n \end{bmatrix} $
$+ (-1)^{n+1} \times (-a_0)(-1)^n $
$ = t[t^{n} - a_{n}t^{n-1} - a_{n-1}t^{n-2} - ... - a_3t^2 - a_2t - a_1] + (-1)^{2n+1} a_0$
$ = t^{n+1} - a_nt^n - a_{n-1}t^{n-1} - ... - a_2t^2 - a_1t - a_0$
Proof complete.
Best Answer
For aesthetic considerations suggested by Michael Hoppe, I'll rename $K$ into $n$ and $y_{K+1}$ into $x_{n+1}$, so the matrix whose determinant you're searching is
$$A=\begin{pmatrix} x_1 & 0 & \dots & 0 & y_1 \\ 0 & x_2 & \dots & 0 & y_2 \\ \vdots & \vdots & \ddots & \vdots & \vdots \\ 0 & 0 & \dots & x_n & y_n \\ y_1 & y_2 & \dots & y_n & x_{n+1} \end{pmatrix}. $$
First method. Use determinant expansion with respect to the last column to get
$$\mathrm{det}(A) = x_1...x_n x_{n+1} + \sum_{i=1}^n(-1)^{n+1+i} \mathrm{det}(A_i)$$
where $A_i$ is the matrix $A$ deprived of its last column and $i$-th row. For example,
$$A_1 = \begin{pmatrix}0& x_2 &0& ... &0 \\ 0 & 0 & x_3 & ... & 0 \\ \vdots & & & \ddots& \vdots\\ 0 & & ... & & x_n\\ y_1 & &... && y_n \\ \end{pmatrix}. $$ Using row expansion for $A_i$, it is easy to see that $\mathrm{det}(A_i)$ is equal to $(-1)^{n+i} y_i \prod_{j \neq i} x_j$, which yelds
\begin{align*}\mathrm{det}(A) &= \prod_{i=1}^{n+1} x_i - \sum_{i=1}^n y_i^2 \prod_{j \neq i, j\leqslant n}x_j \\ &= \prod_{i=1}^{n+1}x_i \left( 1 - \sum_{i=1}^n \frac{y_i^2}{x_i}\right). \end{align*}
Edit (second method, hint). This last expression suggests another method (maybe it's not working) : suppose that no $x_i$ is zero. Note $X = \mathrm{diag}(x_1, ..., x_{n+1})$ and $Y = A - X$, so that $A = X+Y = X(\mathrm{Id}+X^{-1}Y)$. Then, $\mathrm{det}(A) = \mathrm{det}(X) \mathrm{det}(\mathrm{Id} - X^{-1}Y)$. Now, all you have to do is to compute $\mathrm{det}(\mathrm{Id} - X^{-1}Y)$. Maybe there's a simple ay of doing this (I don't know).