Let $S_{a, b, c, d, e} $ be the number of solutions with $x_1\ge a$, $x_2 \ge b$, $x_3\ge c$, $x_4\ge d$ and $x_5\ge e$.
The equation can be written as
$$(x_1-a)+(x_2-b)+(x_3-c)+(x_4-d)+(x_5-e)=21-a-b-c-d-e$$
So we have
$$S_{a, b, c, d, e} =\binom{21-a-b-c-d-e+4}{4}$$
if $a+b+c+d +e\le21$ and is $0$ otherwise.
The answer to this question is
$$S_{0, 1,15,0,0}-S_{4,1,15,0,0}-S_{0,4,15,0,0}+S_{4,4,15,0,0}=\binom{9}{4}-\binom{5}{4}-\binom{6}{4}+0=106$$
As mentioned in the comments, there are three cases: $x_1\in \{1,3,5\}$. That's because the minimum value of $x_2+x_3+x_4+x_5$, when all are positive integers, is $4$ and so the maximum odd value of $x_1$ is $5$. If we set $x_1 =1$, then there are $9$ stars left and $8$ spaces to place $3$ bars since all four remaining variables must be positive integers. This gives ${8\choose 3}=56$ possibilities.
If $x_1 = 3$, there are $6$ spaces for the bars and ${6\choose 3} = 20$ possibilities.
Finally, if $x_1 = 5$, there are $4$ spaces for the bars, for a total of ${4\choose 3} = 4$ possibilities.
Hence there are $56+20+4 = 80$ possibilities in total.
Best Answer
Approach using the rule of product.
Each of these will either have $2$ options (you do include or you don't include), or just one option according to the needs of the particular step of the problem you are on.
Multiply the number of options for each step together to get the total.
$~$
$~$