Solved – coxme proportional hazard assumption

cox-modelr

I am running mixed effect Cox models (I have 1 random effect factor) using the coxme function {coxme} in R, and I would like to check the assumption of proportional hazard.

I know that the proportional hazards (PH) assumption can be verified with the cox.zph function {survival} on cox.ph model.

However, I cannot find the equivalent for coxme models.

In 2015 a similar question has been posted here, but had no answer.

My questions are:

  1. How to test PH assumption on mixed effect cox model coxme?
  2. If there is no equivalent of the cox.zph for coxme models, is it valid for publication in scientific article to run mixed effect coxme model but test the PH assumption on a cox.ph model identical to the coxme model but without random effect?

Best Answer

Apologies for making this a separate answer, but I cannot comment because I have less than 50 reputation.

Oka suggested using frailty in connection with coxph in order to test the proportional hazard assumption. I believe it is worth noting that the documentation for frailty mentions, "the coxme package has superseded this [frailty] method." For this reason, the original question about "how to test the PH assumption on mixed effect cox model coxme," has strong justification to stay within the scope of coxme.

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