The conditions on the covariances will force the $X_i$ to be strongly correlated to one another, and the $Y_j$ to be strongly correlated to each other, when the mutual correlations between the $X_i$ and $Y_j$ are nonzero. As a model to develop intuition, then, let's let both $(X_i)$ and $(Y_j)$ have an exponential autocorrelation function
$$\rho(X_i, X_j) = \rho(Y_i, Y_j) = \rho^{|i-j|}$$
for some $\rho$ near $1$. Also take every $X_i$ and $Y_j$ to have zero expectation and unit variance. Let $\text{Cov}(X_i,Y_j)=\alpha$. (For any given $n$ and $\alpha$, the possible values of $\rho$ will be limited to an interval containing $1$ due to the necessity of creating a positive-definite correlation matrix.)
In this model the covariance (equally well, the correlation) matrix in terms of $(X_1, \ldots, X_n, Y_1, \ldots, Y_n)$ will look like
$$\begin{pmatrix}
1 & \rho & \cdots & \rho^{n-1} & \alpha & \alpha & \cdots & \alpha \\
\rho & 1 & \cdots & \rho^{n-2} & \alpha & \alpha & \cdots & \alpha \\
\vdots & \vdots & \cdots & \vdots & \vdots & \vdots & \cdots & \vdots \\
\rho^{n-1} & \cdots & \rho & 1 & \alpha & \alpha & \cdots & \alpha \\
\alpha & \alpha & \cdots & \alpha & 1 & \rho & \cdots & \rho^{n-1} \\
\alpha & \alpha & \cdots & \alpha &\rho & 1 & \cdots & \rho^{n-2} \\
\vdots & \vdots & \cdots & \vdots & \vdots & \vdots & \cdots & \vdots \\
\alpha & \alpha & \cdots & \alpha & \rho^{n-1} & \cdots & \rho & 1
\end{pmatrix}$$
A simulation (using $2n$-variate Normal random variables) explains much. This figure is a scatterplot of all $(X_i,Y_i)$ from $1000$ independent draws with $\rho=0.99$, $\alpha=-0.6$, and $n=8$.
The gray dots show all $8000$ pairs $(X_i,Y_i)$. The first $70$ of these $1000$ realizations have been separately colored and surrounded by $80\%$ confidence ellipses (to form visual outlines of each group).
The orientations of these ellipses have a uniform distribution: on average, there is no correlation among individual collections $((X_1,Y_1), \ldots, (X_n,Y_n))$.
However, due to the induced positive correlation among the $X_i$ (equally well, among the $Y_j$), all the $X_i$ for any given realization tend to be tightly clustered. From one realization to another they tend to line up along a downward slanting line, with some scatter around it, thereby realizing a cloud of correlation $\alpha=-0.6$.
We might summarize the situation by saying by recentering the data, the sample correlation coefficient does not account for the variation among the means of the $X_i$ and means of the $Y_j$. Since, in this model, the correlation between those two means is exactly the same as the correlation between any $X_i$ and any $Y_j$ (namely $\alpha$), the expected correlation nets out to zero.
Here is working R
code to play with the simulation.
library(MASS)
#set.seed(17)
n.sim <- 1000
alpha <- -0.6
rho <- 0.99
n <- 8
mu <- rep(0, 2*n)
sigma.11 <- outer(1:n, 1:n, function(i,j) rho^(abs(i-j)))
sigma.12 <- matrix(alpha, n, n)
sigma <- rbind(cbind(sigma.11, sigma.12), cbind(sigma.12, sigma.11))
min(eigen(sigma)$values) # Must be positive for sigma to be valid.
x <- mvrnorm(n.sim, mu, sigma)
#pairs(x[, 1:n], pch=".")
library(car)
ell <- function(x, color, plot=TRUE) {
if (plot) {
points(x[1:n], x[1:n+n], pch=1, col=color)
dataEllipse(x[1:n], x[1:n+n], levels=0.8, add=TRUE, col=color,
center.cex=1, fill=TRUE, fill.alpha=0.1, robust=TRUE)
}
v <- eigen(cov(cbind(x[1:n], x[1:n+n])))$vectors[, 1]
atan2(v[2], v[1]) %% pi
}
n.plot <- min(70, n.sim)
colors=rainbow(n.plot)
plot(as.vector(x[, 1:n]), as.vector(x[, 1:n + n]), type="p", pch=".", col=gray(.4),
xlab="X",ylab="Y")
invisible(sapply(1:n.plot, function(i) ell(x[i,], colors[i])))
ev <- sapply(1:n.sim, function(i) ell(x[i,], color=colors[i], plot=FALSE))
hist(ev, breaks=seq(0, pi, by=pi/10))
Best Answer
You will have to know the full joint distribution of $X$ and $Y$ in order to calculate $$E[X/Y] = \int (x/y) p(x,y) ~dx dy. $$
Note that $E[X/Y]$ might not even be defined - this is the case for example when $X$ and $Y$ are normally distributed, and the ratio has a Cauchy distribution which has no mean.
See also Ratio distribution.