Hi,
I am trying to replicate the example "Fit a One-Compartment Model to an Individual's PK Profile" from the sbiofit help page (https://se.mathworks.com/help/simbio/ref/sbiofit.html) but using the SimBiology GUI instead of doing it programmatically; see attached files.
Unfortunately I cannot replicate the results as the fit variables, volume of the central compartment and clearance, are different compared to the values found programmatically (in particular, they are equal to the set initial value). Does anyone know what I am missing?
Also, I have the following additional questions:
- Why is ka_Central not estimated in this case? Shouldn't it be estimated as it is part of the one-compartment model used here?
- What happens if a dose has different units? E.g. gram instead of milligram for this particular example? Does SimBiology automatically detect the different units and convert them appropriately?
Hope my explanation is clear enough,
Many thanks,
Jacopo
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